HIV/AIDS kills around 1.8 million people a year, and ranks as the third
leading cause of death in low-income countries. But a recent study in
journal Blood
presents a potentially new way to combat the disease: instead of
killing the virus, make the body resistant to it. When a person is
infected, the body's innate immune system provides an immediate but
flawed defense; HIV takes its membrane or "skin" from the cell that it
infects.
Researchers led by scientists at Imperial College London
and Johns Hopkins University exposed HIV by removing cholesterol from
this cellular wall, producing a large hole in the virus's membrane and
making it permeable, which in turn led to a stronger adaptive response,
orchestrated by immune cells. While researchers have lengths to go
before they can even think to announce a cure for HIV, this breakthrough
could drastically reduce the amount of resources devoted to treating
and combating the disease and provide insight into fighting similarly
complex diseases in the future.
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